Ramon was the bullpen coach for the Philadelphia Phillies from 1998-2008, and played minor league baseball as an infielder in the Phillies organization from 1982 until 1989. He was born August 18, 1963 in Moncion, Dominican Republic.

Ramon has become best known for his role in the 2005 and 2006 Major League Baseball All-Star Games, where he pitched to the Home Run Derby champions both years (Phillies outfielder Bobby Abreu and Phillies first baseman Ryan Howard, respectively). His performance in the 2005 Derby led to the well-publicized requests of Boston Red Sox designated hitter David Ortiz and Baltimore Orioles shortstop Miguel Tejada to have Henderson pitch to them as well in the 2006 Derby.

Henderson missed most of the 2008 season for personal reasons.

Ramon is married to Sally Henderson, and together they have 2 daughters and 3 sons, all of whom play baseball.